FZD3

Across TCGA cell cohorts, FZD3 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FZD3-associated genes across cancer lineages are TIFAB, ZCCHC13, and IZUMO3. Each is linked with FZD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both FZD3-to-partner and partner-to-FZD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIFAB grouped by FZD3-low versus FZD3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FZD3→partner) and Y-score (partner→FZD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TIFAB →	+0.006	+4.977	<.001	.007	3	1
STOMACH	ZCCHC13 →	+0.033	+5.285	<.001	.003	3	1
BLOOD_Leukemia	IZUMO3 →	+0.073	+5.969	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

TIFAB by FZD3 expression — LARGE_INTESTINE

Explore this box plot interactively →