FZD3

Across TCGA cell cohorts, FZD3 mutation is significantly associated with the mutation status of many other genes, with 1,835 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FZD3-associated genes across cancer lineages are LRP10, IKZF1, and JPH1. Each is linked with FZD3 in more than 3 cancer types. Because this analysis shows association rather than direction, both FZD3-to-partner and partner-to-FZD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRP10 grouped by FZD3-low versus FZD3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FZD3→partner) and Y-score (partner→FZD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LRP10 →	+4.321	+5.285	.005	.005	1	4
BLOOD_Lymphoma	IKZF1 →	+4.584	+4.584	.007	.007	1	4
LARGE_INTESTINE	JPH1 →	+3.672	+4.799	.002	.002	1	4
LARGE_INTESTINE	PUM2 →	+3.350	+4.584	.003	.003	1	3
LARGE_INTESTINE	DHX8 →	+4.087	+5.044	.001	.001	1	3
LARGE_INTESTINE	LRCH4 →	+3.350	+4.584	.003	.003	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,835 associations by consensus.

LRP10 by FZD3 expression — BLOOD_Leukemia

Explore this box plot interactively →