FZD10

Across TCGA patient cohorts, FZD10 mutation is significantly associated with the RNA expression of many other genes, with 5,962 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FZD10-associated genes across cancer lineages are HELLS, WDR41, and ZBTB8OS. Each is linked with FZD10 in more than 3 cancer types. Because this analysis shows association rather than direction, both FZD10-to-partner and partner-to-FZD10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HELLS grouped by FZD10-low versus FZD10-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FZD10→partner) and Y-score (partner→FZD10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	HELLS →	+0.673	+3.321	.003	.009	3	4
STAD	WDR41 →	+0.599	+3.524	<.001	.002	3	4
UCEC	ZBTB8OS →	+0.436	+2.254	<.001	<.001	3	4
STAD	ELAC2 →	+0.564	+3.231	<.001	.008	3	4
UCEC	MRPL42 →	+0.326	+1.732	.005	.001	3	4
UCEC	NARS1 →	+0.524	+2.906	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,962 associations by consensus.

HELLS by FZD10 expression — STAD

Explore this box plot interactively →