FZD10

Across TCGA patient cohorts, FZD10 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FZD10-associated genes across cancer lineages are 4E-BP1, Notch1, and Caspase-7-cleavedD198. Each is linked with FZD10 in more than 2 cancer types. Because this analysis shows association rather than direction, both FZD10-to-partner and partner-to-FZD10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by FZD10-low versus FZD10-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FZD10→partner) and Y-score (partner→FZD10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	4E-BP1 →	+0.331	+3.584	.015	.002	3	3
UCEC	Notch1 →	+0.168	+1.321	<.001	.029	3	3
UCEC	Caspase-7-cleavedD198 →	+0.558	+1.505	.004	.034	3	3
UCEC	Cyclin-B1 →	+0.546	+2.584	.003	<.001	3	3
LUAD	MSH6 →	+0.398	+3.195	.003	.009	3	2
LUAD	TTF1 →	+0.950	+3.182	.026	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

4E-BP1 by FZD10 expression — LUAD

Explore this box plot interactively →