FZD10

Across TCGA cell cohorts, FZD10 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,001 significant associations in total. LUNG_NSCLC_LUSC shows the largest number of these associations.

The most reproducible FZD10-associated GO terms across cancer lineages are Negative regulation of transcription elongation by RNA polymerase II, Regulation of RNA stability, and Regulation of mRNA stability. Each is linked with FZD10 in more than 4 cancer types. Because this analysis shows association rather than direction, both FZD10-to-partner and partner-to-FZD10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of transcription elongation by RNA polymerase II grouped by FZD10-low versus FZD10-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FZD10→partner) and Y-score (partner→FZD10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Negative regulation of transcription elongation by RNA polymerase II →	+0.070	+1.527	.009	.004	3	5
LUNG_NSCLC_LUSC	Regulation of RNA stability →	+0.047	+0.894	<.001	.002	3	5
LUNG_NSCLC_LUSC	Regulation of mRNA stability →	+0.047	+1.376	<.001	.006	3	5
OESOPHAGUS	Protein polyubiquitination →	+0.051	+1.773	.001	.004	3	5
LUNG_NSCLC_LUSC	Positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway →	-0.360	-2.075	.001	.004	3	4
LUNG_NSCLC_LUSC	Regulation of animal organ formation →	-0.294	-1.904	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,001 associations by consensus.

Negative regulation of transcription elongation by RNA polymerase II by FZD10 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →