FZD10

Across TCGA cell cohorts, FZD10 mutation is significantly associated with the RNA expression of many other genes, with 680 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FZD10-associated genes across cancer lineages are FAM120B, FDXACB1, and CCDC163. Each is linked with FZD10 in more than 1 cancer types. Because this analysis shows association rather than direction, both FZD10-to-partner and partner-to-FZD10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM120B grouped by FZD10-low versus FZD10-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FZD10→partner) and Y-score (partner→FZD10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAM120B →	+0.476	+2.158	.009	.004	3	2
LARGE_INTESTINE	FDXACB1 →	+0.524	+2.850	<.001	<.001	3	2
LARGE_INTESTINE	CCDC163 →	+0.647	+2.850	<.001	<.001	3	2
LUNG_SCLC	TRIML1 →	+0.244	+4.269	<.001	.005	3	2
BREAST	REG1B →	+0.790	+5.754	<.001	<.001	3	2
LUNG_NSCLC_LUSC	DCD →	+0.046	+4.643	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 680 associations by consensus.

FAM120B by FZD10 expression — LARGE_INTESTINE

Explore this box plot interactively →