FZD1

Across TCGA patient cohorts, FZD1 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FZD1-associated genes across cancer lineages are JNK2, ATM, and FOXO3a_pS318_S321. Each is linked with FZD1 in more than 3 cancer types. Because this analysis shows association rather than direction, both FZD1-to-partner and partner-to-FZD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by FZD1-low versus FZD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FZD1→partner) and Y-score (partner→FZD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.203	+1.512	.001	.031	3	4
UCEC	ATM →	-0.394	-2.571	.008	.010	3	4
UCEC	FOXO3a_pS318_S321 →	-0.105	-1.938	.011	.001	3	3
UCEC	PDCD4 →	-0.582	-2.238	<.001	.001	3	3
COAD	Stathmin →	+0.163	+3.012	.011	.018	3	3
UCEC	ERK2 →	+0.138	+1.700	.029	.040	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

JNK2 by FZD1 expression — UCEC

Explore this box plot interactively →