FZD1

Across TCGA cell cohorts, FZD1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,536 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible FZD1-associated GO terms across cancer lineages are Astrocyte-dopaminergic neuron signaling, Glial cell-neuron signaling, and Regulation of nucleotide-excision repair. Each is linked with FZD1 in more than 15 cancer types. Because this analysis shows association rather than direction, both FZD1-to-partner and partner-to-FZD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Astrocyte-dopaminergic neuron signaling grouped by FZD1-low versus FZD1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FZD1→partner) and Y-score (partner→FZD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Astrocyte-dopaminergic neuron signaling →	-0.215	-1.391	<.001	<.001	3	16
URINARY_TRACT	Glial cell-neuron signaling →	-0.238	-1.368	<.001	<.001	3	12
BONE	Regulation of nucleotide-excision repair →	+0.103	+1.464	.002	.004	3	12
UPPER_AERODIGESTIVE_TRACT	Regulation of myoblast fusion →	+0.086	+1.046	.001	.005	3	12
UPPER_AERODIGESTIVE_TRACT	Regulation of syncytium formation by plasma membrane fusion →	+0.082	+1.182	<.001	.001	3	11
UPPER_AERODIGESTIVE_TRACT	Midbrain dopaminergic neuron differentiation →	-0.184	-1.479	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,536 associations by consensus.

Astrocyte-dopaminergic neuron signaling by FZD1 expression — BREAST

Explore this box plot interactively →