FZD1

Across TCGA cell cohorts, FZD1 mutation is significantly associated with the RNA expression of many other genes, with 849 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FZD1-associated genes across cancer lineages are C3orf20, LRRC53, and GK2. Each is linked with FZD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FZD1-to-partner and partner-to-FZD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C3orf20 grouped by FZD1-low versus FZD1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FZD1→partner) and Y-score (partner→FZD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C3orf20 →	+0.082	+3.584	<.001	.003	3	2
URINARY_TRACT	LRRC53 →	+0.209	+4.217	.004	.005	3	1
CNS	GK2 →	+0.013	+5.754	<.001	.002	3	1
BLOOD_Lymphoma	REG3G →	+0.049	+5.867	<.001	<.001	3	1
BLOOD_Lymphoma	SLC36A2 →	+0.034	+4.192	<.001	.003	3	1
BLOOD_Lymphoma	KRTAP9-2 →	+0.026	+4.662	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 849 associations by consensus.

C3orf20 by FZD1 expression — LARGE_INTESTINE

Explore this box plot interactively →