FYN

Across TCGA pan-cancer cohorts, FYN Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FYN data layer compared with 26 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher FYN Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated FYN expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

KIRC, SKCM, and UCEC are the cancer types where FYN Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.134	0.811	<.001	30	view →
SKCM	DFS	Median	All	0.372	0.742	.001	15	view →
UCEC	DFS	Median	All	0.922	0.620	.025	14	view →
LUAD	OS	Median	III,IV	0.057	0.680	<.001	12	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FYN–KIRC (OS)

Open the KIRC breakdown →