Across TCGA patient cohorts, FYB2 mutation is significantly associated with the RNA expression of many other genes, with 3,970 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FYB2-associated genes across cancer lineages are CHEK1, FAM136A, and HELLS. Each is linked with FYB2 in more than 3 cancer types. Because this analysis shows association rather than direction, both FYB2-to-partner and partner-to-FYB2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FYB2→partner) and Y-score (partner→FYB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CHEK1 →	+0.565	+2.436	<.001	.001	3	4
UCEC	FAM136A →	+0.355	+2.203	.001	<.001	3	4
UCEC	HELLS →	+0.459	+1.551	.003	.002	3	4
UCEC	MED18 →	+0.401	+1.776	<.001	<.001	3	4
UCEC	CENPO →	+0.450	+2.233	.001	.005	3	4
UCEC	FANCD2 →	+0.576	+3.191	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,970 associations by consensus.

Exploration

FYB2 survival (RNA) · tumor vs normal (RNA) · all FYB2 data types