Across TCGA pan-cancer cohorts, FYB2 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of FYB2’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where FYB2 RNA is repressed in tumor relative to normal tissue. In most cancer types FYB2 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.
KIRC, KIRP, and LUSC are the cancer types where FYB2 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FYB2 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.