FXR1

Across TCGA patient cohorts, FXR1 protein abundance is significantly associated with the RNA expression of many other genes, with 18,662 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible FXR1-associated genes across cancer lineages are RFC4, ECT2, and CENPA. Each is linked with FXR1 in more than 9 cancer types. Because this analysis shows association rather than direction, both FXR1-to-partner and partner-to-FXR1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FXR1 versus RFC4 in LSCC, with a Pearson correlation of 0.74.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FXR1→partner) and Y-score (partner→FXR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RFC4 →	+1.217	+0.558	<.001	<.001	3	10
LSCC	ECT2 →	+1.221	+0.535	<.001	<.001	3	9
BRCA	CENPA →	+1.261	+0.323	<.001	<.001	3	9
LSCC	ACTL6A →	+1.225	+0.595	<.001	<.001	3	9
LSCC	POLR2H →	+0.981	+0.568	<.001	<.001	3	9
LSCC	MFN1 →	+0.978	+0.605	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,662 associations by consensus.

FXR1 vs RFC4 — LSCC

Explore this scatter interactively →