FUZ

Across TCGA pan-cancer cohorts, FUZ Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated FUZ data layer compared with 24 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher FUZ Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated FUZ expression acts as an unfavorable survival marker.

BRCA, ACC, and CHOL are the cancer types where FUZ Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Median	All	0.294	0.902	.001	6	view →
ACC	DFS	Median	All	0.089	0.666	.017	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

FUZ–BRCA (DFS)

Open the BRCA breakdown →