FUZ

Across TCGA pan-cancer cohorts, FUZ RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of FUZ’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where FUZ RNA is repressed in tumor relative to normal tissue. In most cancer types FUZ is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

KICH, LUAD, and CHOL are the cancer types where FUZ tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FUZ RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−1.373	<.001	8	view →
LUAD	All	II,III,IV	−0.469	<.001	7	view →
CHOL	All	All	+2.181	<.001	5	view →
HNSC	All	All	−0.571	.004	4	view →
KIRC	Female	III,IV	+0.322	.015	3	view →
UCEC	All	All	−0.705	.014	2	view →
PAAD	All	All	+0.697	.049	2	view →
LUSC	Female	III,IV	−0.904	.049	1	view →
READ	All	All	−0.864	.013	1	view →
THCA	Male	IV	−0.366	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

FUZ–KICH

Open the KICH breakdown →