FUZ

Across TCGA patient cohorts, FUZ protein abundance is significantly associated with the RNA expression of many other genes, with 4,661 significant associations in total. GBM shows the largest number of these associations.

The most reproducible FUZ-associated genes across cancer lineages are SEZ6L, TTC28, and SEPTIN3. Each is linked with FUZ in more than 1 cancer types. Because this analysis shows association rather than direction, both FUZ-to-partner and partner-to-FUZ results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FUZ versus SEZ6L in GBM, with a Pearson correlation of -0.71.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FUZ→partner) and Y-score (partner→FUZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SEZ6L →	-3.001	-0.456	<.001	<.001	3	1
GBM	TTC28 →	-0.904	-0.355	.006	.009	3	1
GBM	SEPTIN3 →	-1.750	-0.410	.004	.005	3	1
GBM	XBP1 →	+0.958	+0.429	<.001	.001	3	1
GBM	SYNGR1 →	-1.257	-0.373	<.001	<.001	3	1
GBM	TNRC6B →	-0.656	-0.402	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,661 associations by consensus.

FUZ vs SEZ6L — GBM

Explore this scatter interactively →