FUZ

Across TCGA cell cohorts, FUZ mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible FUZ-associated genes across cancer lineages are FEZF2, OR10K2, and PABPC1L2A. Each is linked with FUZ in more than 1 cancer types. Because this analysis shows association rather than direction, both FUZ-to-partner and partner-to-FUZ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FEZF2 grouped by FUZ-low versus FUZ-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FUZ→partner) and Y-score (partner→FUZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	FEZF2 →	+0.016	+5.169	<.001	.005	3	1
BREAST	OR10K2 →	+0.063	+5.781	<.001	.001	3	1
BREAST	PABPC1L2A →	+0.083	+5.169	<.001	.005	3	1
BREAST	OR10T2 →	+0.183	+5.781	<.001	.001	3	1
UPPER_AERODIGESTIVE_TRACT	SCYGR2 →	+0.166	+5.357	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

FEZF2 by FUZ expression — BREAST

Explore this box plot interactively →