FUT8

Across TCGA pan-cancer cohorts, FUT8 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated FUT8 data layer compared with 27 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher FUT8 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated FUT8 expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

LSCC, UCEC, and CCRCC are the cancer types where FUT8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	All	0.635	0.976	.003	27	view →
UCEC	DFS	Median	All	0.823	0.987	<.001	18	view →
CCRCC	DFS	Quartile	II,III,IV	0.123	0.904	.024	16	view →
PDAC	OS	Quartile	II,III,IV	0.950	0.794	.003	8	view →
GBM	OS	Tertile	All	0.424	0.567	.038	4	view →
HNSC	DFS	Quartile	III,IV	0.690	0.420	.021	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

FUT8–LSCC (DFS)

Open the LSCC breakdown →