FUT8

Across TCGA pan-cancer cohorts, FUT8 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of FUT8’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where FUT8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FUT8 is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

HNSC, LUAD, and KIRP are the cancer types where FUT8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FUT8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	+1.111	<.001	11	view →
LUAD	Female	III,IV	+1.568	<.001	9	view →
KIRP	Male	III,IV	+1.467	<.001	9	view →
COAD	Male	All	+1.111	<.001	8	view →
LUSC	Female	II,III,IV	+1.391	<.001	6	view →
READ	All	II,III,IV	+1.239	<.001	6	view →
BRCA	All	III,IV	+1.183	<.001	6	view →
BLCA	All	All	+0.688	.015	6	view →
KICH	Female	All	−1.279	<.001	4	view →
STAD	All	All	+0.772	.002	4	view →
CHOL	All	All	+1.864	.001	2	view →
UCEC	All	All	−0.705	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

FUT8–HNSC

Open the HNSC breakdown →