FUT8

Across TCGA patient cohorts, FUT8 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FUT8-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and A-Raf_pS299. Each is linked with FUT8 in more than 2 cancer types. Because this analysis shows association rather than direction, both FUT8-to-partner and partner-to-FUT8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by FUT8-low versus FUT8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FUT8→partner) and Y-score (partner→FUT8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.687	+2.189	<.001	.001	3	3
UCEC	EGFR_pY1068 →	-0.236	-2.321	.003	.005	3	2
UCEC	A-Raf_pS299 →	-0.079	-1.678	.038	.021	3	2
UCEC	JNK2 →	+0.217	+1.777	<.001	.002	3	2
UCEC	PCNA →	+0.235	+2.058	<.001	<.001	3	2
UCEC	ATM →	-0.397	-2.687	.006	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Caspase-7-cleavedD198 by FUT8 expression — UCEC

Explore this box plot interactively →