FUT10

Across TCGA patient cohorts, FUT10 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FUT10-associated genes across cancer lineages are EGFR_pY1068, ERK2, and MEK1. Each is linked with FUT10 in more than 1 cancer types. Because this analysis shows association rather than direction, both FUT10-to-partner and partner-to-FUT10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by FUT10-low versus FUT10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FUT10→partner) and Y-score (partner→FUT10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.264	-3.700	.006	.001	3	1
UCEC	ERK2 →	+0.180	+2.584	.015	.010	3	1
UCEC	MEK1 →	+0.315	+2.584	.025	.001	3	1
UCEC	MSH2 →	-0.303	-2.433	<.001	.018	3	1
UCEC	MSH6 →	-0.427	-2.115	<.001	.016	3	1
UCEC	PCNA →	+0.178	+1.700	.032	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

EGFR_pY1068 by FUT10 expression — UCEC

Explore this box plot interactively →