FUS

Across TCGA patient cohorts, FUS mutation is significantly associated with the RNA expression of many other genes, with 1,519 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FUS-associated genes across cancer lineages are UHRF1, MMP12, and CCDC43. Each is linked with FUS in more than 1 cancer types. Because this analysis shows association rather than direction, both FUS-to-partner and partner-to-FUS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UHRF1 grouped by FUS-low versus FUS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FUS→partner) and Y-score (partner→FUS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UHRF1 →	+0.652	+2.212	.002	<.001	3	2
COAD	MMP12 →	+1.665	+3.183	.004	.009	3	2
UCEC	CCDC43 →	+0.501	+2.233	<.001	<.001	3	2
UCEC	PRF1 →	+0.692	+2.008	.007	.005	3	2
UCEC	RWDD4 →	+0.540	+2.584	<.001	<.001	3	2
UCEC	SKA2 →	+0.612	+2.212	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,519 associations by consensus.

UHRF1 by FUS expression — UCEC

Explore this box plot interactively →