FURIN

Across TCGA pan-cancer cohorts, FURIN mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated FURIN data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher FURIN mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated FURIN expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

LUAD, PDAC, and UCEC are the cancer types where FURIN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	II,III,IV	0.285	0.837	<.001	50	view →
PDAC	DFS	Median	II,III,IV	0.219	0.493	.004	19	view →
UCEC	OS	Median	III,IV	0.374	1.000	.014	16	view →
LSCC	OS	Tertile	II,III,IV	0.735	0.967	.004	10	view →
CCRCC	OS	Median	All	1.000	0.682	.014	6	view →
GBM	OS	Tertile	All	0.957	0.705	.026	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

FURIN–LUAD (OS)

Open the LUAD breakdown →