FURIN

Across TCGA patient cohorts, FURIN protein abundance is significantly associated with the RNA expression of many other genes, with 7,088 significant associations in total. GBM shows the largest number of these associations.

The most reproducible FURIN-associated genes across cancer lineages are PDIA3, MESD, and HCAR3. Each is linked with FURIN in more than 3 cancer types. Because this analysis shows association rather than direction, both FURIN-to-partner and partner-to-FURIN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FURIN versus PDIA3 in LUAD, with a Pearson correlation of 0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FURIN→partner) and Y-score (partner→FURIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PDIA3 →	+0.495	+0.811	<.001	<.001	3	4
LSCC	MESD →	+0.296	+0.256	<.001	<.001	3	3
LUAD	HCAR3 →	+0.794	+0.580	<.001	.002	3	3
GBM	CEROX1 →	-1.730	-0.391	<.001	<.001	3	3
GBM	PTPRS →	-1.110	-0.504	<.001	<.001	3	3
GBM	DUSP4 →	+1.402	+0.426	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,088 associations by consensus.

FURIN vs PDIA3 — LUAD

Explore this scatter interactively →