FURIN

Across TCGA patient cohorts, FURIN mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FURIN-associated genes across cancer lineages are Caspase-7-cleavedD198, eEF2, and GAPDH. Each is linked with FURIN in more than 3 cancer types. Because this analysis shows association rather than direction, both FURIN-to-partner and partner-to-FURIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by FURIN-low versus FURIN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FURIN→partner) and Y-score (partner→FURIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.684	+1.999	<.001	.008	3	4
COAD	eEF2 →	+0.291	+3.000	.029	.035	2	3
UCEC	GAPDH →	+0.389	+1.514	.016	.014	3	2
UCEC	mTOR_pS2448 →	-0.111	-2.156	.013	.002	3	2
UCEC	Rad50 →	-0.198	-1.321	.006	.012	3	2
UCEC	Rictor_pT1135 →	-0.073	-1.530	.017	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

Caspase-7-cleavedD198 by FURIN expression — UCEC

Explore this box plot interactively →