FURIN

Across TCGA cell cohorts, FURIN RNA expression is significantly associated with the go_rna of many other GO terms, with 5,577 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FURIN-associated GO terms across cancer lineages are Regulation of transforming growth factor beta1 production, Negative regulation of low-density lipoprotein particle receptor catabolic process, and Negative regulation of transforming growth factor beta1 production. Each is linked with FURIN in more than 18 cancer types. Because this analysis shows association rather than direction, both FURIN-to-partner and partner-to-FURIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of transforming growth factor beta1 production grouped by FURIN-low versus FURIN-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FURIN→partner) and Y-score (partner→FURIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of transforming growth factor beta1 production →	+0.261	+1.367	.001	.003	3	19
STOMACH	Negative regulation of low-density lipoprotein particle receptor catabolic process →	+0.328	+1.851	<.001	<.001	2	19
BLOOD_Myeloma	Negative regulation of transforming growth factor beta1 production →	+1.491	+2.122	<.001	<.001	3	18
BLOOD_Myeloma	Negative regulation of receptor catabolic process →	+0.206	+1.680	<.001	<.001	2	18
BREAST	Negative regulation of transforming growth factor beta production →	+0.309	+1.290	<.001	<.001	3	16
STOMACH	Modulation by symbiont of entry into host →	+0.159	+1.729	<.001	.002	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,577 associations by consensus.

Regulation of transforming growth factor beta1 production by FURIN expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →