FURIN

Across TCGA cell cohorts, FURIN mutation is significantly associated with the RNA expression of many other genes, with 632 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FURIN-associated genes across cancer lineages are ZIC5, SRRD, and GCAT. Each is linked with FURIN in more than 1 cancer types. Because this analysis shows association rather than direction, both FURIN-to-partner and partner-to-FURIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZIC5 grouped by FURIN-low versus FURIN-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FURIN→partner) and Y-score (partner→FURIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZIC5 →	+1.325	+3.364	<.001	.002	3	2
LARGE_INTESTINE	SRRD →	+0.866	+3.169	<.001	.009	3	1
LARGE_INTESTINE	GCAT →	+1.441	+3.364	<.001	.002	3	1
LARGE_INTESTINE	ZC3H14 →	+0.602	+3.364	<.001	.002	3	1
LARGE_INTESTINE	ADNP2 →	+0.894	+3.364	<.001	.002	3	1
LARGE_INTESTINE	USP14 →	+0.807	+3.451	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 632 associations by consensus.

ZIC5 by FURIN expression — LARGE_INTESTINE

Explore this box plot interactively →