FURIN

Across TCGA cell cohorts, FURIN mutation is significantly associated with the mutation status of many other genes, with 7,272 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FURIN-associated genes across cancer lineages are PRDM15, ITPR1, and ZNF418. Each is linked with FURIN in more than 4 cancer types. Because this analysis shows association rather than direction, both FURIN-to-partner and partner-to-FURIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRDM15 grouped by FURIN-low versus FURIN-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FURIN→partner) and Y-score (partner→FURIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PRDM15 →	+3.442	+4.558	.003	.003	1	5
BLOOD_Lymphoma	ITPR1 →	+3.362	+4.754	.002	.002	1	5
OVARY	ZNF418 →	+5.415	+5.415	.004	.004	1	5
CNS	PI4KA →	+4.459	+5.277	.005	.005	1	5
BLOOD_Leukemia	GRIK3 →	+3.347	+2.870	.009	.009	1	5
BLOOD_Leukemia	NCOR2 →	+2.347	+3.087	<.001	<.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,272 associations by consensus.

PRDM15 by FURIN expression — BREAST

Explore this box plot interactively →