FUCA2

Across TCGA patient cohorts, FUCA2 mutation is significantly associated with the RNA expression of many other genes, with 2,357 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FUCA2-associated genes across cancer lineages are MIR633, RNA5SP478, and RNU6-1333P. Each is linked with FUCA2 in more than 2 cancer types. Because this analysis shows association rather than direction, both FUCA2-to-partner and partner-to-FUCA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR633 grouped by FUCA2-low versus FUCA2-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FUCA2→partner) and Y-score (partner→FUCA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MIR633 →	+0.306	+5.018	<.001	.004	3	3
HNSC	RNA5SP478 →	+0.373	+5.008	<.001	.004	3	2
CESC	RNU6-1333P →	+0.535	+3.944	<.001	.007	3	2
BRCA	RN7SKP221 →	+0.099	+8.471	<.001	.005	3	2
HNSC	GRPEL2P2 →	+0.111	+5.654	<.001	<.001	3	2
CESC	RNA5SP198 →	+0.218	+4.559	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,357 associations by consensus.

MIR633 by FUCA2 expression — BLCA

Explore this box plot interactively →