FUCA2

Across TCGA pan-cancer cohorts, FUCA2 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of FUCA2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where FUCA2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FUCA2 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, KIRP, and BLCA are the cancer types where FUCA2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FUCA2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.373	<.001	12	view →
KIRP	Male	II,III,IV	+0.885	<.001	11	view →
BLCA	All	III,IV	+0.977	<.001	10	view →
KIRC	Female	All	+0.407	<.001	9	view →
KICH	Female	II,III,IV	−1.469	<.001	8	view →
STAD	Male	II,III,IV	+1.335	<.001	8	view →
LIHC	Female	All	+0.856	<.001	7	view →
UCEC	All	All	+0.613	<.001	6	view →
LUAD	All	II,III,IV	+0.443	<.001	6	view →
BRCA	Female	All	+0.273	<.001	6	view →
COAD	Male	All	+0.428	.001	4	view →
CHOL	Male	All	+1.385	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

FUCA2–HNSC

Open the HNSC breakdown →