FUCA2

Across TCGA patient cohorts, FUCA2 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FUCA2-associated genes across cancer lineages are PI3K-p110-a, Shc_pY317, and VHL. Each is linked with FUCA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FUCA2-to-partner and partner-to-FUCA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PI3K-p110-a grouped by FUCA2-low versus FUCA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FUCA2→partner) and Y-score (partner→FUCA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PI3K-p110-a →	-0.174	-3.807	.016	<.001	3	2
UCEC	Shc_pY317 →	-0.226	-3.000	<.001	.001	3	2
UCEC	VHL →	-0.948	-2.321	<.001	.033	3	2
UCEC	eEF2 →	+0.516	+3.459	<.001	.005	3	1
UCEC	EGFR_pY1068 →	-0.334	-2.807	.001	.003	3	1
UCEC	eIF4E →	+0.222	+2.321	.010	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

PI3K-p110-a by FUCA2 expression — UCEC

Explore this box plot interactively →