FUCA2

Across TCGA cell cohorts, FUCA2 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible FUCA2-associated genes across cancer lineages are AKAP4, MT1H, and C2CD4B. Each is linked with FUCA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FUCA2-to-partner and partner-to-FUCA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AKAP4 grouped by FUCA2-low versus FUCA2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FUCA2→partner) and Y-score (partner→FUCA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	AKAP4 →	+0.010	+3.544	.001	.009	3	1
LUNG_NSCLC_LUAD	MT1H →	+0.749	+3.866	.008	.006	3	1
SKIN	C2CD4B →	+0.065	+4.684	<.001	.002	3	1
URINARY_TRACT	C16orf90 →	+0.023	+5.087	<.001	.004	3	1
LARGE_INTESTINE	L3MBTL4 →	+0.634	+3.285	.003	.007	1	1
SKIN	PPEF2 →	+0.034	+4.877	<.001	.001	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

AKAP4 by FUCA2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →