FTO

Across TCGA cell cohorts, FTO mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible FTO-associated genes across cancer lineages are ACSM6, IQCM, and FGF6. Each is linked with FTO in more than 1 cancer types. Because this analysis shows association rather than direction, both FTO-to-partner and partner-to-FTO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACSM6 grouped by FTO-low versus FTO-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FTO→partner) and Y-score (partner→FTO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACSM6 →	+0.023	+3.658	<.001	.005	3	1
BLOOD_Leukemia	IQCM →	+0.045	+4.922	<.001	.009	3	1
LUNG_NSCLC_LUAD	FGF6 →	+0.243	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR10AG1 →	+0.043	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	PABPC1L2A →	+0.045	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	POU3F4 →	+0.284	+4.887	.006	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

ACSM6 by FTO expression — LARGE_INTESTINE

Explore this box plot interactively →