FTMT

Across TCGA patient cohorts, FTMT mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FTMT-associated genes across cancer lineages are 4E-BP1_pT70, PKC-delta_pS664, and 4E-BP1. Each is linked with FTMT in more than 1 cancer types. Because this analysis shows association rather than direction, both FTMT-to-partner and partner-to-FTMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1_pT70 grouped by FTMT-low versus FTMT-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FTMT→partner) and Y-score (partner→FTMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	4E-BP1_pT70 →	+0.179	+2.602	.032	.006	3	2
UCEC	PKC-delta_pS664 →	-0.099	-1.584	.034	.036	3	2
UCEC	4E-BP1 →	+0.351	+2.730	<.001	.003	3	2
LUAD	P-Cadherin →	+0.279	+2.824	.022	.036	3	1
SKCM	CDK1 →	+0.387	+3.000	<.001	.034	3	1
UCEC	EGFR_pY1068 →	-0.288	-2.700	.003	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

4E-BP1_pT70 by FTMT expression — SKCM

Explore this box plot interactively →