FTMT

Across TCGA cell cohorts, FTMT mutation is significantly associated with the RNA expression of many other genes, with 59 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FTMT-associated genes across cancer lineages are KLHL40, OR2B3, and OR10C1. Each is linked with FTMT in more than 1 cancer types. Because this analysis shows association rather than direction, both FTMT-to-partner and partner-to-FTMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLHL40 grouped by FTMT-low versus FTMT-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FTMT→partner) and Y-score (partner→FTMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KLHL40 →	+0.006	+5.209	.006	.005	3	2
UPPER_AERODIGESTIVE_TRACT	OR2B3 →	+0.075	+4.736	<.001	.009	3	2
UPPER_AERODIGESTIVE_TRACT	OR10C1 →	+0.105	+4.736	<.001	.009	3	2
LARGE_INTESTINE	PRMT9 →	+0.728	+3.192	<.001	.007	3	2
PANCREAS	TBL1Y →	+0.004	+4.029	<.001	.007	3	1
OVARY	ASB17 →	+0.014	+4.222	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

KLHL40 by FTMT expression — BLOOD_Lymphoma

Explore this box plot interactively →