FTHL18

Across TCGA patient cohorts, FTHL18 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,879 significant associations in total. STAD shows the largest number of these associations.

The most reproducible FTHL18-associated GO terms across cancer lineages are DNA-templated transcription termination, Regulation of double-strand break repair via nonhomologous end joining, and Regulation of insulin receptor signaling pathway. Each is linked with FTHL18 in more than 7 cancer types. Because this analysis shows association rather than direction, both FTHL18-to-partner and partner-to-FTHL18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA-templated transcription termination grouped by FTHL18-low versus FTHL18-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FTHL18→partner) and Y-score (partner→FTHL18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	DNA-templated transcription termination →	+0.100	+0.043	<.001	.004	3	8
ESCA	Regulation of double-strand break repair via nonhomologous end joining →	+0.088	+0.043	<.001	.003	3	7
STAD	Regulation of insulin receptor signaling pathway →	+0.080	+0.024	<.001	<.001	3	7
STAD	Regulation of cell division →	+0.078	+0.028	<.001	<.001	3	7
ESCA	Reactive oxygen species metabolic process →	+0.088	+0.068	<.001	.001	3	6
ESCA	Organelle membrane fusion →	+0.099	+0.039	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,879 associations by consensus.

DNA-templated transcription termination by FTHL18 expression — ESCA

Explore this box plot interactively →