FSTL5

Across TCGA patient cohorts, FSTL5 mutation is significantly associated with the RNA expression of many other genes, with 5,605 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FSTL5-associated genes across cancer lineages are DDX55, RFC5, and OTX1. Each is linked with FSTL5 in more than 4 cancer types. Because this analysis shows association rather than direction, both FSTL5-to-partner and partner-to-FSTL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DDX55 grouped by FSTL5-low versus FSTL5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FSTL5→partner) and Y-score (partner→FSTL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DDX55 →	+0.336	+1.683	<.001	.001	3	5
UCEC	RFC5 →	+0.466	+1.593	<.001	.002	3	5
STAD	OTX1 →	+0.639	+2.415	.001	.003	3	5
STAD	FAM136A →	+0.455	+2.618	<.001	.004	3	5
UCEC	HSPA14 →	+0.357	+1.369	.002	.003	3	5
STAD	CHCHD3 →	+0.368	+3.559	.004	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,605 associations by consensus.

DDX55 by FSTL5 expression — UCEC

Explore this box plot interactively →