FSTL5

Across TCGA pan-cancer cohorts, FSTL5 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of FSTL5’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where FSTL5 RNA is repressed in tumor relative to normal tissue. In most cancer types FSTL5 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, HNSC, and KICH are the cancer types where FSTL5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FSTL5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	−0.067	<.001	9	view →
HNSC	All	II,III,IV	+0.531	.002	8	view →
KICH	All	All	−0.057	<.001	7	view →
LIHC	Male	All	+0.792	<.001	5	view →
LUSC	Male	All	+0.454	<.001	4	view →
READ	All	All	−0.404	.009	4	view →
COAD	Male	All	−0.171	.025	2	view →
LUAD	Male	II,III,IV	+0.173	.027	1	view →
THCA	Female	III,IV	+0.015	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

FSTL5–KIRC

Open the KIRC breakdown →