FSTL5

Across TCGA cell cohorts, FSTL5 mutation is significantly associated with the RNA expression of many other genes, with 265 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FSTL5-associated genes across cancer lineages are OR6M1, ZBTB8A, and OR1P1. Each is linked with FSTL5 in more than 1 cancer types. Because this analysis shows association rather than direction, both FSTL5-to-partner and partner-to-FSTL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6M1 grouped by FSTL5-low versus FSTL5-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FSTL5→partner) and Y-score (partner→FSTL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	OR6M1 →	+0.020	+4.807	<.001	.006	3	2
LARGE_INTESTINE	ZBTB8A →	+0.638	+2.502	.001	.005	3	2
LUNG_NSCLC_LUAD	OR1P1 →	+0.022	+2.887	<.001	.009	3	2
SOFT_TISSUE	IFNA13 →	+0.072	+4.930	<.001	.008	3	1
BONE	LAIR2 →	+0.043	+5.169	<.001	.004	3	1
BONE	LIPK →	+0.023	+5.169	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 265 associations by consensus.

OR6M1 by FSTL5 expression — BLOOD_Myeloma

Explore this box plot interactively →