FSTL3

Across TCGA patient cohorts, FSTL3 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FSTL3-associated genes across cancer lineages are eIF4E, YB-1, and Cyclin-B1. Each is linked with FSTL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both FSTL3-to-partner and partner-to-FSTL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by FSTL3-low versus FSTL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FSTL3→partner) and Y-score (partner→FSTL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.259	+3.000	.033	.037	2	1
UCEC	YB-1 →	-0.186	-2.973	.043	.037	1	1
UCEC	Cyclin-B1 →	+0.767	+3.000	.018	.037	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

eIF4E by FSTL3 expression — UCEC

Explore this box plot interactively →