FSTL3

Across TCGA pan-cancer cohorts, FSTL3 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated FSTL3 data layer compared with 6 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher FSTL3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated FSTL3 expression acts as an unfavorable survival marker, although some lineages such as UVM and KIRP show a favorable association.

LUSC, MESO, and COAD are the cancer types where FSTL3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	All	0.599	0.746	<.001	110	view →
MESO	OS	Median	All	0.404	0.694	<.001	103	view →
COAD	DFS	Median	All	0.715	0.848	<.001	86	view →
OV	DFS	Quartile	II,III,IV	0.421	0.555	.006	66	view →
UCEC	OS	Tertile	All	0.880	0.945	<.001	58	view →
LUAD	DFS	Median	All	0.592	0.733	<.001	52	view →
HNSC	DFS	Quartile	All	0.603	0.773	<.001	52	view →
LGG	DFS	Median	All	0.268	0.503	<.001	48	view →
CESC	DFS	Tertile	All	0.769	0.921	<.001	48	view →
GBM	DFS	Tertile	All	0.182	0.324	.003	35	view →
UVM	DFS	Median	III,IV	0.644	0.277	.004	20	view →
STAD	DFS	Tertile	II,III,IV	0.574	0.801	.006	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

FSTL3–LUSC (OS)

Open the LUSC breakdown →