FSTL3

Across TCGA cell cohorts, FSTL3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,528 significant associations in total. BONE shows the largest number of these associations.

The most reproducible FSTL3-associated GO terms across cancer lineages are Protein activation cascade, Collagen fibril organization, and Wound healing. Each is linked with FSTL3 in more than 15 cancer types. Because this analysis shows association rather than direction, both FSTL3-to-partner and partner-to-FSTL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein activation cascade grouped by FSTL3-low versus FSTL3-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FSTL3→partner) and Y-score (partner→FSTL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Protein activation cascade →	+0.341	+2.071	.001	<.001	3	16
BONE	Collagen fibril organization →	+0.451	+2.275	<.001	<.001	3	15
BONE	Wound healing →	+0.139	+1.950	<.001	<.001	3	15
BONE	Integrin-mediated signaling pathway →	+0.323	+2.641	<.001	<.001	3	14
BONE	Regulation of extracellular matrix disassembly →	+0.179	+1.551	.004	.006	2	14
BONE	Regulation of cell-substrate adhesion →	+0.157	+2.424	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,528 associations by consensus.

Protein activation cascade by FSTL3 expression — UPPER_AERODIGESTIVE_TRACT

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