FST

Across TCGA patient cohorts, FST mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FST-associated genes across cancer lineages are ATM, 4E-BP1, and EGFR_pY1068. Each is linked with FST in more than 1 cancer types. Because this analysis shows association rather than direction, both FST-to-partner and partner-to-FST results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by FST-low versus FST-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FST→partner) and Y-score (partner→FST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.626	-3.161	.001	.019	3	2
COAD	4E-BP1 →	+0.255	+3.000	.018	.035	3	2
UCEC	EGFR_pY1068 →	-0.213	-2.999	.035	.035	3	2
UCEC	MEK1 →	+0.296	+1.874	.044	.049	3	2
UCEC	Shc_pY317 →	-0.170	-2.999	.005	.035	3	2
UCEC	Cyclin-B1 →	+0.527	+3.169	.019	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

ATM by FST expression — COAD

Explore this box plot interactively →