FST

Across TCGA pan-cancer cohorts, FST RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of FST’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where FST RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FST is over-expressed in tumor, although a few such as KIRP and KICH show the opposite, repressed pattern.

HNSC, KIRP, and KICH are the cancer types where FST tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FST RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+3.581	<.001	12	view →
KIRP	Male	II,III,IV	−1.584	<.001	11	view →
KICH	Male	II,III,IV	−1.515	<.001	9	view →
LUSC	All	II,III,IV	+2.625	<.001	8	view →
KIRC	Male	II,III,IV	−1.189	<.001	7	view →
THCA	All	II,III,IV	−0.824	<.001	6	view →
COAD	Female	II,III,IV	−0.668	.008	4	view →
BRCA	All	All	−0.640	<.001	4	view →
CHOL	All	II,III,IV	−2.920	.017	3	view →
BLCA	Male	All	−1.303	.028	2	view →
UCEC	All	All	−1.182	.002	2	view →
PRAD	All	All	−0.842	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

FST–HNSC

Open the HNSC breakdown →