FST

Across TCGA cell cohorts, FST RNA expression is significantly associated with the go_rna of many other GO terms, with 5,050 significant associations in total. BONE shows the largest number of these associations.

The most reproducible FST-associated GO terms across cancer lineages are Cell-substrate junction organization, Cell-substrate junction assembly, and Blood coagulation, fibrin clot formation. Each is linked with FST in more than 10 cancer types. Because this analysis shows association rather than direction, both FST-to-partner and partner-to-FST results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cell-substrate junction organization grouped by FST-low versus FST-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FST→partner) and Y-score (partner→FST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Cell-substrate junction organization →	+0.203	+3.936	<.001	<.001	3	11
OESOPHAGUS	Cell-substrate junction assembly →	+0.202	+3.483	<.001	<.001	3	10
OESOPHAGUS	Blood coagulation, fibrin clot formation →	+0.395	+3.214	<.001	.001	3	10
SKIN	Positive regulation of transmission of nerve impulse →	+1.096	+2.975	<.001	<.001	3	10
SKIN	Positive regulation of wound healing →	+0.096	+2.966	<.001	<.001	3	10
BONE	Positive regulation of canonical NF-kappaB signal transduction →	+0.055	+2.998	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,050 associations by consensus.

Cell-substrate junction organization by FST expression — OESOPHAGUS

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