FST

Across TCGA cell cohorts, FST mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FST-associated genes across cancer lineages are OTOP1, ITGAD, and SCGB3A2. Each is linked with FST in more than 1 cancer types. Because this analysis shows association rather than direction, both FST-to-partner and partner-to-FST results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OTOP1 grouped by FST-low versus FST-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FST→partner) and Y-score (partner→FST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OTOP1 →	+0.210	+5.087	<.001	.004	3	1
LARGE_INTESTINE	ITGAD →	+0.015	+4.095	<.001	.009	3	1
LARGE_INTESTINE	SCGB3A2 →	+0.384	+4.095	<.001	.009	3	1
LARGE_INTESTINE	BPIFA1 →	+0.287	+4.273	<.001	.006	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.015	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

OTOP1 by FST expression — URINARY_TRACT

Explore this box plot interactively →