FSIP1

Across TCGA patient cohorts, FSIP1 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FSIP1-associated genes across cancer lineages are eIF4E, IGFBP2, and ATM. Each is linked with FSIP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FSIP1-to-partner and partner-to-FSIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by FSIP1-low versus FSIP1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FSIP1→partner) and Y-score (partner→FSIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	eIF4E →	+0.201	+1.700	.007	.043	3	2
SKCM	IGFBP2 →	-0.503	-2.906	.019	.001	3	2
UCEC	ATM →	-0.620	-3.794	<.001	<.001	3	2
SKCM	FASN →	+0.422	+3.000	.040	.034	3	2
SKCM	Bim →	-0.385	-1.700	<.001	.043	3	2
UCEC	14-3-3_beta →	-0.115	-2.780	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

eIF4E by FSIP1 expression — SKCM

Explore this box plot interactively →