FSHR

Across TCGA cell cohorts, FSHR mutation is significantly associated with the RNA expression of many other genes, with 54 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FSHR-associated genes across cancer lineages are LY6G6F, ASB10, and MYL10. Each is linked with FSHR in more than 1 cancer types. Because this analysis shows association rather than direction, both FSHR-to-partner and partner-to-FSHR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LY6G6F grouped by FSHR-low versus FSHR-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FSHR→partner) and Y-score (partner→FSHR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	LY6G6F →	+0.036	+4.643	<.001	.008	3	1
BLOOD_Leukemia	ASB10 →	+0.092	+4.551	<.001	.004	3	1
STOMACH	MYL10 →	+0.195	+4.129	<.001	.007	3	1
LUNG_NSCLC_LUAD	CABP5 →	+0.236	+2.896	<.001	.008	3	1
LUNG_NSCLC_LUAD	GRK7 →	+0.085	+3.478	<.001	.005	3	1
LUNG_NSCLC_LUAD	CLRN1 →	+0.014	+3.944	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

LY6G6F by FSHR expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →