FRZB

Across TCGA patient cohorts, FRZB mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible FRZB-associated genes across cancer lineages are Macrophages, Astrocytes, and naive B-cells. Each is linked with FRZB in more than 1 cancer types. Because this analysis shows association rather than direction, both FRZB-to-partner and partner-to-FRZB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Macrophages grouped by FRZB-low versus FRZB-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRZB→partner) and Y-score (partner→FRZB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Macrophages →	+0.030	+3.288	.006	.041	3	2
SKCM	Astrocytes →	+0.076	+2.825	<.001	.027	3	1
CESC	naive B-cells →	+0.007	+3.337	.049	.032	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Macrophages by FRZB expression — COAD

Explore this box plot interactively →