FRZB

Across TCGA cell cohorts, FRZB mutation is significantly associated with the RNA expression of many other genes, with 359 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FRZB-associated genes across cancer lineages are GNPNAT1, ZFYVE21, and PPP4R3A. Each is linked with FRZB in more than 1 cancer types. Because this analysis shows association rather than direction, both FRZB-to-partner and partner-to-FRZB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GNPNAT1 grouped by FRZB-low versus FRZB-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRZB→partner) and Y-score (partner→FRZB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GNPNAT1 →	+0.750	+2.451	<.001	.009	3	1
LARGE_INTESTINE	ZFYVE21 →	+0.451	+3.502	.005	.001	3	1
LARGE_INTESTINE	PPP4R3A →	+0.572	+2.451	<.001	.009	3	1
LARGE_INTESTINE	YY1 →	+0.516	+3.131	.001	.008	3	1
LARGE_INTESTINE	VAPA →	+0.572	+3.169	.001	.006	3	1
LARGE_INTESTINE	MTFMT →	+0.557	+3.502	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 359 associations by consensus.

GNPNAT1 by FRZB expression — LARGE_INTESTINE

Explore this box plot interactively →